Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor Expression, and T Cell Lineage Commitment
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چکیده
منابع مشابه
Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment.
T cell differentiation in the thymus is dependent upon signaling through the TCR and is characterized by the resulting changes in expression patterns of CD4 and CD8 surface coreceptor molecules. Although recent studies have characterized the effects of proximal TCR signaling on T cell differentiation, the downstream integration of these signals remains largely unknown. The growth factor indepen...
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